Cytotoxic immunological synapses
نویسندگان
چکیده
منابع مشابه
Cytotoxic immunological synapses.
One of the most fundamental activities of the adaptive immune system is to kill infected cells and tumor cells. Two distinct pathways mediate this process, both of which are facilitated by a cytotoxic immunological synapse. While traditionally thought of as innate immune cells, natural killer (NK) cells are now appreciated to have the capacity for long-term adaptation to chemical and viral insu...
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Rodrigo Siqueira-Batista1, Mauro Geller2 and Andréia Patrícia Gomes3 1Professor of Internal Medicine, Neuroscience and Immunology/Microbiology, Centro Universitário Serra dos Órgãos (UNIFESO); 2Professor of Immunology and Microbiology, Centro Universitário Serra dos Órgãos (UNIFESO); Coordinator of Genodermatosis, Genetic Services, Instituto Puericultura e Pediatria Martagão Gesteira (IPPMG), F...
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C D8 cytotoxic T lymphocytes (CTLs) provide defense against intracellular pathogens and tumors by recognizing and subsequently destroying infected or transformed cells. Recognition is achieved by T cell receptors (TCRs) on the CTL binding to non-self-peptide fragments presented in the cleft of class I MHC molecules (peptide–MHC complexes) on the surface of the target cell. TCR ligation triggers...
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Following antigen recognition on target cells, effector T cells establish immunological synapses and secrete cytokines. It is thought that T cells secrete cytokines in one of two modes: either synaptically (i.e., toward antigenic target cells) or multidirectionally, affecting a wider population of cells. This paradigm predicts that synaptically secreted cytokines such as IFN-γ will preferential...
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Dendritic cells (DCs) are myeloid lineage cells that are imprinted by their environment and that mature in response to microbial products. A crucial role of the DC is to impart this context-specific information to T cells as well as to present self and foreign MHC-peptide complexes through formation of an immunological synapse. The structure of the T cell-DC immunological synapse departs from t...
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ژورنال
عنوان ژورنال: Immunological Reviews
سال: 2010
ISSN: 0105-2896
DOI: 10.1111/j.0105-2896.2010.00904.x